RT-28
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New insight on pacing induced
effects
on the myocardium through in ovo pacing
of chick-embryo heart
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Lukas Kappenberger, Michel
Grobéty, Christophe Reymond, David Sedmera, Pavel Kucera.
Division of Cardiology, CHUV and Institute of Physiology of the University of Lausanne,
Switzerland
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Abstract
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The primary goal of electric stimulation of the heart
was the treatment of arrhythmias. For many years, bradycardia pacing remained the only
indication for pacemaker treatment and it is still the primary one. However, it became
obvious that pacing modifies hemodynamics and attempts to get more physiologic pacing
resulted in rate responsive and dual chamber pacing. Nevertheless, it was realised that a
pacemaker activated beat was not the same as a His-Purkinje activated beat. The underlying
mechanism to this difference has not been deeply investigated so far. We therefore
developed a novel model to investigate morphological changes induced by ectopic
stimulation of the heart. We achieved reliable stimulation of the chick-embryo heart for
48 hours reflecting approximately 10 cell turn-over-cycles. With this experimental set-up
structural changes of the heart can be analysed morphologically, histologically and on
molecular level.
So far, our experiment allows to conclude that pacing modulates indeed the structure
of the heart by a mechanism which is not related to the platelet-derived-growth-factor.
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Key Words
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Pacing
morphological and biological changes of myocardium, structure of the heart, OA
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