Giuseppe Boriani, Mauro Biffi,
Alessandro Capucci*, Gianluca Botto**, Tiziana Broffoni**, Maurizio Ongari°, Giuseppe
Trisolino°°°, Ida Rubino°°, Mario Sanguinetti°°, Angelo Branzi, Bruno Magnani.
Institute of Cardiology, University of Bologna; *Civil Hospitals Piacenza,
**Como, °Porretta, °°Lugo, °°°Dept. of Emergency, S. Orsola Hospital, Bologna, Italy
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We examined in a patient population of 417 patients
(pts) the efficacy and safety of different therapeutic strategies for converting
recent-onset atrial fibrillation (AF) (< 7 days duration) to sinus rhythm (SR).
All the pts were in NYHA Class < 2, without signs or symptoms of heart failure
and were hospitalised.
The pts were randomly allocated to treatment with one of the following drugs: iv
amiodarone (iv AM) (5mg/kg as bolus, then 1.8 gr/24 hours) (51 pts), iv propafenone (iv
PF) (2mg/kg as bolus, then 0.0078 mg/kg/min) (57 pts), oral loading with propafenone (oral
PF) (600 mg po as single dose) (119 pts) and oral loading with flecainide (oral FL) (300
mg po as single dose) (69 pts).
All the pts were submitted to Holter monitoring and conversions to SR were evaluated
at 1.3 and 8 hours.
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