RT-128
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Apoptosis, cardiomyopathies and
arrhythmias
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Marialuisa Valente, Fiorella
Calabrese, Cristina Basso, Annalisa Angelini, Gaetano Thiene.
Department of Pathology University of Padua, Medical School, Padua, Italy
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Abstract
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Apoptosis is an energy requiring process of individual
cell death which can be genetically determined or may be triggered by external factors. It
plays a role in morphogenesis and in cell turnover; in the heart it is involved in normal
postnatal involution of the right ventricular myocardium and in many pathological
conditions. Its presence has been documented in arrhytmogenic right ventricular
cardiomyopathy and in other syndromes characterised by arrhythmias. Apoptotic bouts in
right ventricular myocardium may cause arrhythmias because they increase excitability of
dying myocytes and cause alteration of normal right ventricular activation.
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Key Words
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Molecular biology - structural anatomy,
pathology
apoptosis, arrhythmogenic right ventricular cardiomyopathy, programmed cell death, cardiac
morphogenesis, apoptic bouts, arrhythmogenesis, R
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