RT-130
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Effect of combination of
beta-blockers and amiodarone in preventing malignant ventricular arrhythmias
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Fulvio Bellocci, Giuseppe De
Martino, Fabrizio Clementi, Vincenzo Affinito, Roberto Bock, Annibale Sandro Montenero,
Paolo Zecchi.
Universita Cattolica del Sacro Cuore, Istituto di Cardiologia, Rome, Italy
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Abstract
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The results of randomised prospective trials and
meta-analysis studies have demonstrated that in high-risk patient for sudden cardiac death
(patient with previous myocardial infarction or congestive heart failure) b-blockers and amiodarone are the only two classes of drugs that
improved survival rate. An important finding from both CAMIAT and EMIAT studies is the
demonstration of an important synergistic interaction between b-blockers
and amiodarone. Despite the clear evidence of efficacy of b-blockers
these drugs are still underused. The best available antiarrhythmic medical therapy should
include b-blockers alone or in combination with amiodarone.
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Key Words
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Treatment of arrhythmias - Pharmacological
management of malignant ventricular arrhythmias
malignant ventricular arrhythmias, sudden death, beta-blockers, amiodarone, synergistic
interaction, CAMIAT trial, EMIAT trial, GESICA trial, CHF-STAT trial, SCD-HeFT trial,
MADIT II trial, CASCADE trial, ESVEM trial, CASH trial, CIDS trial, AVID trial, R
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