RT-133
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Role of thrombus formation in
arrhythmogenesis during acute ischaemia
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Michiel J. Janse, Ruben Coronel,
Francien J.G. Wilms-Schopman.
Department of Clinical and Experimental Cardiology, Academic Medical Center,
University of Amsterdam, Interuniversity Cardiology Institute, The Netherlands (ICIN),
Utrecht, The Netherlands
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Abstract
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Many factors determine the incidence of lethal
arrhythmias during acute ischaemia: size of the ischaemic area, degree of collateral flow,
heart rate, activity of the autonomous nervous system, presence of a previous infarct,
presence of hypertrophy. Recently, it was observed that thrombus formation has an
arrhythmogenic effect over and above that of the arrest of coronary flow. We showed that
this profibrillatory effect is present only during a first period of ischaemia and is
confined to the first 4 to 5 minutes following thrombotic coronary artery occlusion. It is
related to a greater slowing of conduction, a larger degree of ST elevation, and a larger
number of sites showing conduction block, compared to coronary occlusion produced by
clamping of the artery.
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Key Words
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Arrhytmhogenesis
thrombus fomation, acute ischemia, ST-changes, conductin delay, OA
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