RT-172
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Heart rate dependency of
ventricular repolarization in congenital and acquired long QT syndrome: long-term analysis
by Holter monitoring
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Emanuela H. Locati.
Division of Cardiology, Department of Clinical Medicine, Pathology and
Pharmacology, University of Perugia, Italy, Heart Research, Department of Cardiology,
University of Rochester, Rochester, USA
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In the last decade the computerized analysis of Holter
recordings has evolved from the simple evaluation of cardiac arrhythmias and ST changes to
the long-term analysis of heart rate variability, and more recently of ventricular
repolarization dynamics. The new generation of digital Holter recorders has improved the
quality of ECG recordings, and enhanced the capability of data analysis by down-loading
the acquired data into personal computers with dedicated analysis programs. These new
computerized analyses can contribute to explore the interaction between the autonomic
nervous system and the myocardial substrate, to identify subjects at risk of arrhythmias
and death in a variety of cardiac conditions.
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Key Words
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RR interval, repolarization, heterogeneity,
variability
Holter ECG, ventricular repolarization dynamics, QT interval, QR-RR relation, LQT
syndrome, LQT genotype, d-sotalol, quinidine, circadian patterns, ST changes, risk
stratification, autonomic nervous system, R
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