RT-173
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Relationship between RR and
variability. A measure of dispersion of ventricular repolarisation
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Federico Lombardi, Andrea
Colombo, Alberto Porta*, Giuseppe Baselli*, Sergio Cerutti*.
Division of Cardiology, Institute of Biomedical Sciences, S. Paolo Hospital,
University of Milan, *Department of Bioengineering, Polytechnic of Milan, Italy
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Abstract
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To evaluate the dynamic characteristics of the
coupling between RT and RR interval we analysed RR/RT-apex variability interaction with a
dynamic parametric model whose parameters can be directly estimated from the beat to beat
series RR and RT-apex intervals. The model is designed to separate the fraction of RT-apex
variability driven by RR changes from that independent of RR variations and to quantify
the gain and phase of the relationship between RR and RT-apex intervals. In normal subject
at rest, most of the variability detectable in the RT-apex signal reflects the spontaneous
oscillations of RR interval, particularly in correspondence of the low and high frequency
components. The determination of the RT percent power independent of RR changes could be
used to quantify the degree of uncoupling between the two signals thus providing a new and
non invasive index of dispersion of ventricular repolarisation.
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Key Words
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RR interval, repolariozation, heterogeneity,
variability
dispersion of ventricular repolarisation, RR variability, RR/RT-apex varibility
interaction, RR-QT coupling, ventricular repolarization duration, OA
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