S-64
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The mechanisms of
arrhythmogenesis
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Michiel J. Janse.
Department of Clinical and Experimental Cardiology, Academic Medical Center,
University of Amsterdam, Interuniversity Cardiology Institute, The Netherlands (ICIN),
Utrecht, The Netherlands
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Abstract
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A general overview is given of arrhythmogenic
mechanisms such as enhanced normal and abnormal automaticity, triggered activity and
re-entry. It is emphasised that usually an arrhythmia is due to more than one
arrhythmogenic mechanism. A brief discussion is provided regarding the question whether
the trigger or the substrate of the arrhythmia should be abolished to effectively prevent
arrhythmias.
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Key Words
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Molecular biology - mechanisms of
arrhythmogenesis
automacity, triggered activity, reentry, CAST trial, R
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