RT-199
|
The antiarrhythmic properties of angiotensin converting enzyme inhibitors and angiotensin II receptor blockers
|
|
|
Pablo I. Altieri, María Crespo, Nelson Escobales, José F. Rodríguez, Héctor Banch.
Departments of Medicine, Physiology and Biochemistry, Medical Sciences Campus, University of Puerto Rico
|
|
Abstract
|
|
We will describe our experience with the mechanisms how angiotensin
converting enzyme inhibitors and angiotensin II receptor blockers act as antiarrhythmic agents reducing the
incidence of malignant arrhythmias and sudden death.
Clinical trials with Angiotensin II Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers have
shown a reduction in sudden death1,3. The reason for this is unknown, but we think this is due to a
reduction of ventricular arrhythmias. We have published that Angiotensin Converting Enzyme Inhibitors
given to hypertensive and ischemic heart patients reduces the incidence of ventricular arrhythmias4,5.
We will discuss in this article our experience with these drugs and discuss the possible mechanisms
involved in the reduction of malignant arrhythmias in patients with hypertensive cardiovascular disease
and ischemic heart disease.
|
Key Words
|
|
|
