RT-201
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Non cardiovascular drugs’ proarrhythmic effect
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Teodomiro Lanzetta, Nedo Svetoni, Gennaro Miracapillo*.
Cardiovascular Lab, Grosseto, *UO Malattie Cardiovascolari, Ospedale Misericordia, Grosseto, Italy
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Abstract
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Proarrhythmic action of antiarrhythmic drugs has been more and more
described in the last years whereas is less known and perhaps underestimated an analogous action due to non
cardiac drugs that, expecially when associated, can induce both hypo and hyperkinetic life-threatening
arrhythmias. Gastroenterological drugs, anaesthetics, antibiotics, antimicrobials, a lot of drugs acting on central
nervous system, antihystaminics and other endogenous or exogenous substances seem to have proarrhythmic
action not only in laboratory experiments but also in clinical setting. Considering the trend to an increased use
of pharmacological associations it will be necessary to have the greatest care in the prescription of these drugs
selecting the patients at risk of arrhythmias and monitoring their electrophysiologic behaviour.
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Key Words
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